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Eprazinone dihydrochloride

CAS No. 10402-53-6

Eprazinone dihydrochloride ( —— )

产品货号. M10205 CAS No. 10402-53-6

Eprazinone 2HClide 是一种具有溶解粘液、溶解分泌物和支气管解痉作用的化合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥267 有现货
100MG ¥437 有现货
500MG ¥1401 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Eprazinone dihydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Eprazinone 2HClide 是一种具有溶解粘液、溶解分泌物和支气管解痉作用的化合物。
  • 产品描述
    Eprazinone 2hydrochloride is a drug with proposed mucolytic, secretolytic, and bronchial antispasmodic properties.(In Vitro):Eprazinone specifically displaces binding to the NK1R. Although Eprazinone displays a rather weak inhibition of [125I]BH-SP binding to NK1R, at a concentration of 25 μM, and an antagonistic effect of about 30%, NK1R blockade could contribute to its mucolytic activity.(In Vivo):Eprazinone (50-200 mg/kg; oral gavage; daily; for 4 days; adult male rats) at a dose of 200 mg/kg significantly increases total and individual (with the exception of phosphatidylinositol) phospholipid levels and decreases total neutral lipids. Lower doses of Eprazinone significantly decrease neutral lipid levels without affecting the phospholipids.In airway epithelial studies, mucosal addition of Eprazinone produces a dose-dependent partially reversible decrease in short-circuit current (Isc). The decrease in Isc at lower Eprazinone concentrations is accounted for entirely by a decrease in net chloride secretion while at higher concentrations both sodium and chloride transport are affected.
  • 体外实验
    Eprazinone specifically displaces binding to the NK1R. Although Eprazinone displays a rather weak inhibition of [125I]BH-SP binding to NK1R, at a concentration of 25 μM, and an antagonistic effect of about 30%, NK1R blockade could contribute to its mucolytic activity.
  • 体内实验
    Eprazinone (50-200 mg/kg; oral gavage; daily; for 4 days; adult male rats) at a dose of 200 mg/kg significantly increases total and individual (with the exception of phosphatidylinositol) phospholipid levels and decreases total neutral lipids. Lower doses of Eprazinone significantly decrease neutral lipid levels without affecting the phospholipids.In airway epithelial studies, mucosal addition of Eprazinone produces a dose-dependent partially reversible decrease in short-circuit current (Isc). The decrease in Isc at lower Eprazinone concentrations is accounted for entirely by a decrease in net chloride secretion while at higher concentrations both sodium and chloride transport are affected. Animal Model:Adult male pathogen free Fischer 344 inbred rats (200-250 g) Dosage:50 mg/kg, 100 mg/kg, and 200 mg/kg Administration:Oral gavage; daily; for 4 days Result:At a dose of 200 mg/kg significantly increased total and individual (with the exception of phosphatidylinositol) phospholipid levels and decreased total neutral lipids.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Other Indications
  • 适应症
    ——

化学信息

  • CAS Number
    10402-53-6
  • 分子量
    453.44
  • 分子式
    C24H32N2O2·2HCl
  • 纯度
    >98% (HPLC)
  • 溶解度
    Water: 18 mg/mL (39.69 mM); DMSO: 1 mg/mL (2.2 mM)
  • SMILES
    Cl.Cl.CCOC(CN1CCN(CC(C)C(=O)C2=CC=CC=C2)CC1)C1=CC=CC=C1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Thrall RS, et al. Exp Lung Res, 1992, 18(3), 409-420.
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